NCT07178210

Robotic-Enabled Microsurgical Intervention for Neurodegenerative Disease

Robotic-Enabled Microsurgical Intervention for Neurodegenerative Disease - A Global, Prospective, Early Feasibility Study in Alzheimer's Patients

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (estimated)
• Sponsor: MMI (Medical Microinstruments, Inc.) · Industry
• Sex: All
• Age: 50 Years
• Healthy volunteers: Not accepted

Summary

The objective of this investigational device exemption (IDE) study is to evaluate the safety and feasibility of using the Symani System and microsurgical techniques in the deep cervical lymph node (dCLN) region in the setting of mild to moderate Alzheimer's disease and lymphatic abnormalities.

Detailed description

A prospective, multi-center, early feasibility study, designed to evaluate the Symani System's safety and feasibility for performing microsurgical techniques in the dCLN region to improve clearance of neurotoxins, such as amyloid-beta and phosphorylated tau, in patients with confirmed mild to moderate Alzheimer's disease and lymphatic abnormalities in the dCLN region.

Conditions

• Alzheimer Disease
• Lymphatic Obstruction

Interventions

Type	Name	Description
DEVICE	Symani Surgical System	Use of Symani Surgical System for performing microsurgical techniques in the deep cervical lymph nodes.

Timeline

• Start date: 2026-03-31
• Primary completion: 2026-08-31
• Completion: 2027-08-31
• First posted: 2025-09-17
• Last updated: 2026-04-15

Locations

2 sites across 1 country: United States

Regulatory

• FDA-regulated device study