NCT07174167

Genicular Nerve Block in Chronic Knee Osteoarthritis

Effectiveness of Genicular Nerve Block on Pain and Disability in Chronic Knee Osteoarthritis: A Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 81 (actual)
• Sponsor: Haydarpasa Numune Training and Research Hospital · Academic / Other
• Sex: All
• Age: 45 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to evaluate whether genicular nerve block (GNB) is effective in reducing pain in patients with knee osteoarthritis. It will also assess the comparative efficacy of different injection protocols. The main questions it aims to answer are: Does genicular nerve block with corticosteroid and local anesthetic provide superior pain relief compared with local anesthetic alone or placebo? Are there differences in clinical outcomes between the three treatment groups? Researchers will compare three groups: GNB with corticosteroid plus local anesthetic GNB with local anesthetic alone Sham procedure with saline (placebo control) Participants will: Receive the assigned injection protocol in accordance with their group Be evaluated at baseline and scheduled follow-up visits for pain intensity and functional status Report their pain scores and functional limitations using standardized assessment tools

Conditions

• Gonarthrosis; Primary
• Genicular Nerve Block
• Gonarthritis

Interventions

Type	Name	Description
DRUG	Genicular nerve block with prilocaine	ultrasound guided genicular nerve block (GNB) injecting 6 mL of 2% prilocaine to the genicular nerves
DRUG	genicular nerve block with prilocaine and triamcinolone	ultrasound guided genicular nerve block (GNB) injecting 5 mL of 2% prilocaine in combination with 1 mL/40 mg of triamcinolone to the genicular nerves
DRUG	Sham injection	placebo injection using 6 mL of 0.9% saline to knee region other than genicular nerves

Timeline

• Start date: 2023-04-01
• Primary completion: 2024-02-10
• Completion: 2024-07-01
• First posted: 2025-09-15
• Last updated: 2025-11-28

Locations

1 site across 1 country: Turkey (Türkiye)