NCT07174128

Two Cut-Off Values of Plethysmographic Variability Index to Guide Intraoperative Fluid Therapy on Serum Lactate in Patients Undergoing Excision of Supra-Tentorial Brain Tumors

Effect of Two Cut-Off Values of Plethysmographic Variability Index to Guide Intraoperative Fluid Therapy on Serum Lactate in Patients Undergoing Excision of Supra-Tentorial Brain Tumors: A Randomized Controlled Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (actual)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aimed to compare two cut-off values of plethysmographic variability index (PVI) -guided fluid therapy in patients undergoing supra-tentorial mass excision regarding immediate postoperative serum lactate.

Detailed description

Fluid therapy in patients undergoing craniotomy is very critical; hypovolemia might decrease cerebral perfusion, while fluid overinfusion might cause brain swelling that impairs surgical removal of lesions. The plethysmographic variability index (PVI) is one of the dynamic indices of fluid responsiveness, a simple, automatic, non-invasive, and continuous method based on calculating changes in the perfusion index (PI).

Conditions

• Cut-Off Value
• Plethysmographic Variability Index
• Intraoperative
• Fluid Therapy
• Serum Lactate
• Excision
• Supra-Tentorial Brain Tumors

Interventions

Type	Name	Description
OTHER	Fluid Therapy	Patients would receive the second round of fluid loading if the Plethysmographic Variability Index (PVI) was 14%.
OTHER	Fluid Therapy	Patients would receive the second round of fluid loading if the Plethysmographic Variability Index (PVI) was 20%.

Timeline

• Start date: 2025-02-20
• Primary completion: 2025-08-24
• Completion: 2025-08-24
• First posted: 2025-09-15
• Last updated: 2025-09-15

Locations

1 site across 1 country: Egypt