NCT07167082

Hand Grip Strength and Prognosis in Hospitalized Cancer Patients

Hospitalized Cancer Patients: Prognostic Value of Hand Grip Strength - A Prospective Cohort Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 130 (actual)
• Sponsor: Ankara Etlik City Hospital · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This prospective cohort study aims to investigate the relationship between hand grip strength and prognosis in hospitalized cancer patients. Hand grip strength, a simple, rapid, and non-invasive measure of overall muscle function, is increasingly recognized as an indicator of frailty, nutritional status, and physical health. The study will evaluate whether lower hand grip strength is associated with higher short-term mortality (30-day all-cause mortality) and adverse clinical outcomes, including ICU admission, hospital readmission, and functional decline.

Detailed description

Hand grip strength declines with age and is associated with frailty, sarcopenia, and cancer cachexia. It is a reliable prognostic marker in cancer patients. In this prospective cohort study, hospitalized patients with pathologically confirmed cancer will undergo hand grip strength measurement within the first 24 hours of admission using a calibrated hand dynamometer. Measurements will be performed on the dominant hand, with patients seated, following international standardized procedures. Three consecutive measurements will be obtained, and the average value will be recorded. Assessments will be conducted by oncology clinicians trained in the protocol. Patients will be followed for 30 days to evaluate primary and secondary endpoints, including all-cause mortality, functional decline, length of hospital stay, intensive care unit admission, readmission, and major complications.

Conditions

• Cancer
• Hospitalizations
• Sarcopenia
• Cachexia; Cancer; Sarcopenia

Interventions

Type	Name	Description
OTHER	Hand Grip Strength Measurement	Hand grip strength will be measured within the first 24 hours of hospitalization using a calibrated hand dynamometer. Measurements will be performed on the dominant hand, with patients seated, following standardized international procedures. Three consecutive measurements will be obtained, and the average value will be recorded. The test is non-invasive, quick, and performed by oncology clinicians trained in the protocol.

Timeline

• Start date: 2024-09-01
• Primary completion: 2024-10-20
• Completion: 2025-03-25
• First posted: 2025-09-11
• Last updated: 2025-09-11

Locations

1 site across 1 country: Turkey (Türkiye)