NCT07166848

Electrostimulation Study for Ocular Graft vs. Host Disease

Pilot Trial of Non-invasive Electrostimulation in Chronic Ocular Graft-vs-Host Disease

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (estimated)
• Sponsor: Zhonghui K. Luo, MD, PhD · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This trial is testing to see if electrostimulation treatment (ET) will be effective in treating those with ocular Graft vs. Host Disease.

Detailed description

The trial is to test whether transcutaneous electrical stimulation (TES) may be an effective new type of non-invasive treatment for patients who are diagnosed with chronic ocular Graft-vs-Host Disease. Such a treatment can potentially decrease the need for the patients to apply eye drops frequently, repair the damage caused by chronic ocular Graft-vs-Host Disease, and improve the comfort of the eyes naturally.

Conditions

• Chronic Ocular Graft-versus-host Disease

Interventions

Type	Name	Description
DEVICE	Electrodes with Currents	Electrodes will be placed on the cheeks and forehead, and treated with an amplitude of 300 µA for 30 mins
DEVICE	Electrodes without Currents	Electrodes will be placed on the cheeks and forehead, and treated with an no amplitude for 30 mins

Timeline

• Start date: 2025-11-30
• Primary completion: 2028-11-30
• Completion: 2029-11-30
• First posted: 2025-09-10
• Last updated: 2025-12-17

Locations

1 site across 1 country: United States