NCT07166809

The Effect of DNS-Based Training Combined With PFMT on LUTS and Pelvic Floor Functions in Women With MS

The Effect of Dynamic Neuromuscular Stabilization-Based Training Combined With Pelvic Floor Muscle Training on Lower Urinary Tract Symptoms and Pelvic Floor Functions in Women With Multiple Sclerosis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Ondokuz Mayıs University · Academic / Other
• Sex: Female
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The goal of this randomized controlled trial is to investigate whether adding Dynamic Neuromuscular Stabilization (DNS)-based training to Pelvic Floor Muscle Training (PFMT) can improve lower urinary tract symptoms (LUTS) and pelvic floor functions in women with multiple sclerosis (MS), aged 28-54 years. The main questions it aims to answer are: Does DNS combined with PFMT improve lower urinary tract symptoms more effectively than PFMT alone? Does DNS combined with PFMT enhance pelvic floor muscle function more effectively than PFMT alone? Researchers will compare PFMT alone versus PFMT combined with DNS-based stabilization exercises to see if DNS provides additional benefits. Participants will: Perform an 8-week remotely monitored Pelvic Floor Muscle Training program. In the DNS+PFMT group, complete supervised Dynamic Neuromuscular Stabilization exercises three times a week. Undergo assessments including: Urinary Symptom Profile questionnaire and uroflowmetry for objective evaluation of lower urinary tract symptoms, International Consultation on Incontinence Questionnaire-Short Form, Overactive Bladder Questionnaire (8-item version), Vaginal palpation using the PERFECT (Power, Endurance, Repetitions, Fast contractions, Every Contraction Timed) scheme, Electromyography (muscle electrical activity measurement) for pelvic floor muscles, Magnetic Resonance Imaging (MRI) for diaphragm function evaluation.

Conditions

• Women With Multiple Sclerosis
• Multiple Sclerosis
• Lower Urinary Track Symptoms
• Pelvic Floor Disorder

Interventions

Type	Name	Description
OTHER	Pelvic Floor Muscle Training (PFMT)	A structured pelvic floor muscle training program delivered remotely for 8 weeks, including exercises designed to strengthen and improve the endurance, coordination, and control of the pelvic floor muscles.
OTHER	Pelvic Floor Muscle Training combined with Dynamic Neuromuscular Stabilization (PFMT+DNS)	Participants received the same 8-week remotely monitored pelvic floor muscle training program as the PFMT group, in addition to supervised Dynamic Neuromuscular Stabilization exercises three times per week. DNS exercises aimed to enhance core stability, postural control, and coordination to support pelvic floor muscle function.

Timeline

• Start date: 2023-09-01
• Primary completion: 2024-09-27
• Completion: 2025-08-27
• First posted: 2025-09-10
• Last updated: 2025-09-10

Locations

1 site across 1 country: Turkey (Türkiye)