NCT07166432

Development, Application, and Mechanistic Investigation of a Novel Minimally-Invasive Bidirectional Epidural Cerebellar Stimulation Technique for Cerebellar Cognitive Affective Syndrome

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Peking University First Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

Building on previous findings regarding microglial immune function and the immunosuppressive effects of glucocorticoids, this project centers on the cerebellum's role in cognitive science. Using Cushing's syndrome-induced cerebellar atrophy leading to CCAS as a model, we aim to elucidate the pathogenic mechanisms governed by the neuro-adrenal-immune network and to uncover the molecular basis by which a novel minimally invasive brain-machine fusion system ameliorates cerebellar ataxia and cognitive impairment.

Conditions

• Cerebellar Atrophy
• Etiology
• Physiopathology

Interventions

Type	Name	Description
OTHER	observational diagnostic model development	observational diagnostic model development

Timeline

• Start date: 2025-06-28
• Primary completion: 2028-06-01
• Completion: 2028-06-01
• First posted: 2025-09-10
• Last updated: 2025-09-10

Locations

1 site across 1 country: China