NCT07164196

Endometriosis-Angiopoietin-like Protein-4

Evaluation of Angiopoietin-like Protein 4 Levels in Patients With Endometriosis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 80 (actual)
• Sponsor: Ankara City Hospital Bilkent · Academic / Other
• Sex: Female
• Age: 18 Years – 44 Years
• Healthy volunteers: Accepted

Summary

Endometriosis is a chronic inflammatory disease associated with pelvic pain, dyspareunia, and impaired ovarian reserve. Cancer antigen-125 (CA-125) is widely studied but limited by low specificity, while angiopoietin-like protein-4 (ANGPTL4) has emerged as a potential biomarker due to its role in angiogenesis and inflammation. In the current study it was aimed to investigate serum and peritoneal fluid ANGPTL4 levels in women with endometriosis compared to healthy controls, and to evaluate their associations with clinical symptoms, serum CA-125, and anti-Müllerian hormone levels.

Conditions

• Endometriosis
• Angiopoietin-like Protein-4
• Pelvic Pain

Interventions

Type	Name	Description
OTHER	Angiopoietin-like protein-4 (ANGPTL4) Peritoneal Fluid Level	Measurement of peritoneal fluid levels of Angiopoietin-like protein-4 (ANGPTL4) level by ELISA method.
OTHER	Cancer Antigen 125 (CA-125) Serum Level	Measurement of venous blood serum level of CA-125 level by ELISA method.
OTHER	Angiopoietin-like protein-4 (ANGPTL4) Serum Level	Measurement of venous blood serum level of Angiopoietin-like protein-4 (ANGPTL4) Level level by ELISA method.

Timeline

• Start date: 2025-06-05
• Primary completion: 2025-08-21
• Completion: 2025-09-02
• First posted: 2025-09-10
• Last updated: 2025-09-10

Locations

1 site across 1 country: Turkey (Türkiye)