NCT07163923

MIND Diet in Relation to Malnutrition and Depression in AD

The Role of the MIND Diet in Alzheimer's Disease Patients: A Case-Control Study on Malnutrition and Depression

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: Abant Izzet Baysal University · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Accepted

Summary

The aim of this study was to examine the association between depression, malnutrition, and the Mediterranean-Dietary Approaches to Stop Hypertension Diet Intervention for Neurodegenerative Delay (MIND) diet in Alzheimer's disease patients. This study included 30 patients with Alzheimer's disease (AD) and 30 healthy controls. A questionnaire form including sociodemographic characteristics was applied to the individuals. In addition, anthropometric measurements, biochemical parameters, nutritional status (Food Frequency Questionnaire (FFQ), Mini Nutritional Assessment-Short Form (MNA-SF), Geriatric Nutritional Risk Index (GNRI) and MIND diet scores) and mental health status (Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI)).

Detailed description

Significant progress has been made in understanding the neurobiological basis and treatment approaches for Alzheimer's disease (AD) and depression; however, the biological link between these two disorders has not yet been fully elucidated. A deeper understanding of this relationship could contribute to the development of more effective strategies for the prevention and treatment of both conditions. In this context, lifestyle-based interventions, such as nutrition, which have been shown to support cognitive health, emerge as a potential preventive and therapeutic approach. Therefore, the aim of this study was to examine the relationship between depression, malnutrition, and the Mediterranean-Dietary Approaches to Stop Hypertension Diet Intervention for Neurodegenerative Delay (MIND) diet in individuals with AD.

Conditions

• Alzheimer Disease (AD)
• Healthy Controls Group - Age and Sex-matched

Timeline

• Start date: 2024-06-15
• Primary completion: 2024-10-15
• Completion: 2024-10-15
• First posted: 2025-09-09
• Last updated: 2025-09-09

Locations

1 site across 1 country: Turkey (Türkiye)