Trials / Recruiting
RecruitingNCT07163858
Postural Mobilization Compared to Noradrenaline Only in Off-Pump CABG Surgery
Comparison of Hemodynamic Management by Postural Mobilization Versus Chemical Vasoconstriction Using Noradrenaline Exclusively in Off-pump Coronary Artery Bypass Graft Surgery: A Prospective, Randomized, Comparative, Single-center Study.
- Status
- Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- Sponsor
- Infirmerie Protestante de Lyon · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
This interventional prospective randomized study is designed to compare hemodynamic management using postural mobilization (+/- noradrenaline) versus noradrenaline only in patients undergoing open-heart coronary artery bypass graft (CABG) surgery.
Detailed description
OPTICAB is a single-site study in France that aims to compare two hemodynamic management techniques during off-pump coronary artery bypass graft (CABG) surgery: postural mobilization (+/- noradrenaline) versus noradrenaline only. Primary objective is to evaluate how often noradrenaline is needed when managing hemodynamics using postural mobilization (passive leg raising) during off-pump CABG surgery. The study will also compare revascularization rate and post-operative complications among both groups, and assess perioperative hemodynamic management during the 30-day follow up period.
Conditions
- Coronary Artery Disease With Need for Bypass Surgery
- Coronary Artery Disease(CAD)
- Coronary Artery Bypass
- Off Pump Coronary Artery Bypass Graft
- Off Pump Coronary Artery Bypass Surgery
- Hemodynamic Management
- Hemodynamic Optimization
- Noradrenaline
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | passive leg raising for hemodynamic management during open-heart coronary bypass grafting | Passive leg raising will be used in the experimental group in order to manage hemodynamics: legs will be raised to an angle of approx. 45° |
| PROCEDURE | Use of Noradrenaline only in control group | Noradrenaline will be used for hemodynamic management. Passive leg raising will not be used in this group |
Timeline
- Start date
- 2025-10-06
- Primary completion
- 2027-07-01
- Completion
- 2027-08-01
- First posted
- 2025-09-09
- Last updated
- 2025-12-03
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT07163858. Inclusion in this directory is not an endorsement.