NCT07163286

Malnutrition and Sarcopenia Screening in Chemotherapy Patients

Evaluation and Comparison of Malnutrition and Sarcopenia Risk Using PG-SGA, MUST, Nutriscore, and GLIM Criteria in Cancer Patients Undergoing Chemotherapy

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Çanakkale Onsekiz Mart University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study will include approximately 150 adult outpatients diagnosed with solid tumors who are currently receiving chemotherapy. Both early and advanced stage patients of any sex aged 18 and older will be included, provided they are clinically stable and able to participate in the assessments.

Detailed description

Background: Malnutrition and sarcopenia are prevalent and clinically significant conditions in cancer patients receiving chemotherapy. Accurate nutritional screening and early diagnosis of sarcopenia are critical for improving treatment outcomes and quality of life. Several screening tools are used for nutritional risk assessment in oncology, including PG-SGA, MUST, Nutriscore, and the recently proposed GLIM criteria. Objective: This cross-sectional study aims to evaluate the risk of malnutrition and sarcopenia in solid tumor outpatients receiving chemotherapy. It compares the effectiveness and correlation of PG-SGA, MUST, Nutriscore, and GLIM criteria, and investigates their association with sarcopenia, measured via handgrip strength and CT-based skeletal muscle index at the L3 level. Methods: Approximately 150 adult cancer patients receiving active outpatient chemotherapy will be assessed. Nutritional status will be evaluated using PG-SGA, MUST, Nutriscore, and GLIM. Sarcopenia will be determined via handgrip strength testing and analysis of CT images. Charlson Comorbidity Index will be used to assess comorbidity burden.

Conditions

• Nutrition Aspect of Cancer
• Sarcopenia
• Chemotherapeutic Agent Toxicity

Timeline

• Start date: 2025-07-01
• Primary completion: 2025-12-01
• Completion: 2026-04-01
• First posted: 2025-09-09
• Last updated: 2025-09-09

Locations

1 site across 1 country: Turkey (Türkiye)