NCT07163156

Prolactin, Inflammation, and Parkinson's Severity

The Relationship of Prolactin and Inflammatory Markers With Parkinson's Disease Severity: Clinical and Biochemical Evaluation

• Status: Enrolling By Invitation
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: Çanakkale Onsekiz Mart University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

This cross-sectional observational study aims to evaluate the relationship between serum prolactin levels, peripheral inflammatory markers (NLR, PLR, SII, CRP), and disease severity in patients with Parkinson's disease (PD). A total of at least 300 patients diagnosed with idiopathic PD will be included. Disease severity will be assessed using the Unified Parkinson's Disease Rating Scale (UPDRS) and the Modified Hoehn-Yahr staging system. Serum and salivary prolactin levels will be measured using ELISA, while inflammatory markers will be calculated from routine blood tests. The study seeks to clarify whether prolactin and systemic inflammation indicators may serve as non-invasive biomarkers for disease progression and prognosis in PD, with particular emphasis on postmenopausal women.

Conditions

• Idiopathic Parkinson Disease
• Prolactin
• Prolactin Levels
• Inflammation

Timeline

• Start date: 2025-08-14
• Primary completion: 2025-12-01
• Completion: 2026-06-01
• First posted: 2025-09-09
• Last updated: 2025-09-09

Locations

1 site across 1 country: Turkey (Türkiye)