NCT07162974

Litholytic Therapy for Coral Urate Nephrolithiasis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 49 (actual)
• Sponsor: Moscow State University of Medicine and Dentistry · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

This is a prospective cohort study, patients with coralloid nephrolithiasis. Purpose of the study: to evaluate the efficacy and safety of litholytic therapy of coral-like urate nephrolithiasis with citrate mixtures.

Detailed description

Anthropometric parameters height and weight were recorded in all patients, body mass index was calculated. All patients underwent MSCT of the urinary tract to assess the volume of density and concrements before the start of therapy. Biochemical blood analysis included determination of creatinine level with subsequent calculation of SCF. Urine pH was monitored for 72 hours using an electronic pH meter before therapy and recorded in a diary by patients three times a day, after which the average pH was calculated. Patients who met the inclusion criteria were included in the study after signing informed consent.

Conditions

• Urolithiasis

Interventions

Type	Name	Description
DRUG	anhydrous citric acid - 1197.0 mg, potassium bicarbonate - 967.5 mg, sodium citrate anhydrous - 835.5 mg	The dosage was selected individually for each patient, the target pH was considered to be 7.2

Timeline

• Start date: 2023-01-01
• Primary completion: 2024-10-30
• Completion: 2025-01-09
• First posted: 2025-09-09
• Last updated: 2025-09-09

Locations

1 site across 1 country: Russia