NCT07156799

Kaempferol Gel , Alkaline Phosphatase Activity , Bone Density Around Dental Implants

Influence of Kaempferol Gel on Alkaline Phosphatase Activity and Bone Density Around Dental Implants: A Randomized Controlled Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Al-Azhar University · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Kaempferol gel was tested as a local adjunct during implant placement in 30 patients. Compared to controls, the Kaempferol group showed significantly higher ALP activity at 2 and 4 weeks and greater bone density gain after 6 months (40.73% vs. 33.21%). These findings suggest Kaempferol enhances early bone remodeling, improves peri-implant bone quality, and may allow earlier implant loading.

Detailed description

This randomized controlled clinical trial investigated the effect of Kaempferol gel, a natural antioxidant and bone-healing compound, on dental implant healing in the maxillary posterior region. Thirty patients were divided into two groups: one received Kaempferol gel during implant placement, while the other did not. The study measured alkaline phosphatase (ALP) activity in peri-implant crevicular fluid at 1, 2, and 4 weeks, and bone density using CBCT at baseline and 6 months. Results showed that Kaempferol significantly boosted ALP activity at 2 and 4 weeks, suggesting faster bone remodeling. At 6 months, bone density improved in both groups, but the Kaempferol group showed a greater increase (40.73% vs. 33.21%). In conclusion, Kaempferol gel enhanced early bone healing and improved bone density around implants, indicating its potential as a cost-effective, biocompatible adjunct to accelerate osseointegration and possibly allow earlier implant loading, particularly in patients with poor bone quality.

Conditions

• Peri-implant Bone Healing and Osseointegration

Interventions

Type	Name	Description
DRUG	Kaempferol Gel	Local topical application of Kaempferol gel into the implant site during one-stage delayed implant placement to enhance peri-implant bone healing and osseointegration.

Timeline

• Start date: 2023-06-05
• Primary completion: 2024-06-10
• Completion: 2024-12-07
• First posted: 2025-09-05
• Last updated: 2025-09-05

Locations

1 site across 1 country: Egypt