NCT07156344

Assessing Vulnerability and Outcomes of Intracranial Atherosclerotic Plaques

An Observational Cohort Study on the Identification and Outcome Evaluation of Intracranial Atherosclerotic Plaque Vulnerability

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 3,849 (actual)
• Sponsor: Xuanwu Hospital, Beijing · Academic / Other
• Sex: All
• Age: 30 Years – 80 Years
• Healthy volunteers: —

Summary

This prospective cohort study aims to establish a large-scale cohort for primary stroke prevention in asymptomatic intracranial atherosclerosis (ICAS). Objectives include: characterizing risk factor and stenotic artery distributions; determining optimal TCD screening sentinel arteries; observing plaque progression/regression via HR-MRI; establishing vulnerable plaque evaluation systems through stroke event follow-up; and developing cognitive decline prediction models integrating hemodynamic parameters. All procedures (TCD, HR-MRI, neuropsychological assessments) are routine clinical examinations with minimal risk. Participation is voluntary. Initial TCD and qualifying HR-MRI scans incur standard fees; all follow-up imaging and neuropsychological assessments post-enrollment are provided free of charge.

Conditions

• Asymptomatic Intracranial Atherosclerotic Stenosis Patients

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Progression and Outcome of Intracranial Atherosclerosis	"Progression and Outcome of Intracranial Atherosclerosis" is the primary endpoint; all others are secondary endpoints. Stroke defined as any stroke and new ipsilateral stroke (including ischemic and hemorrhagic stroke) associated with vascular stenosis.

Timeline

• Start date: 2019-01-01
• Primary completion: 2025-04-30
• Completion: 2025-04-30
• First posted: 2025-09-05
• Last updated: 2025-09-05

Locations

1 site across 1 country: China