NCT07154186

Triglycerides Glucose Index on Angiographic Profiling of Non-Diabetic Premature Coronary Artery Disease Patients

Impact of Triglycerides Glucose Index on Angiographic Profiling of Non-Diabetic Premature Coronary Artery Disease Patients

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 180 (estimated)
• Sponsor: Sohag University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to evaluate the impact of the triglyceride-glucose (TyG) index on the angiographic profiling of non-diabetic patients with premature coronary artery disease (CAD).

Detailed description

Premature coronary artery disease (CAD), defined as CAD occurring before the age of 55 in men and 65 in women, has emerged as a growing health concern worldwide. Insulin resistance and associated metabolic alterations are strongly implicated in premature atherosclerosis. Even in non-diabetic individuals, subclinical insulin resistance promotes endothelial dysfunction, oxidative stress, and low-grade inflammation, leading to early vascular damage. The triglyceride-glucose (TyG) index, calculated using fasting glucose and triglyceride levels, has emerged as a cost-effective surrogate marker for insulin resistance.

Conditions

• Triglycerides Glucose Index
• Angiographic Profiling
• Non-Diabetic
• Premature
• Coronary Artery Disease

Interventions

Type	Name	Description
OTHER	Coronary Angiographic Assessment	Coronary angiographic assessment will be performed for all patients.

Timeline

• Start date: 2025-09-04
• Primary completion: 2026-02-01
• Completion: 2026-02-01
• First posted: 2025-09-04
• Last updated: 2025-09-05

Locations

1 site across 1 country: Egypt