NCT07153627

Rectal Ozone as Neuroprotector Post CNS Insult in Children

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Al-Azhar University · Academic / Other
• Sex: All
• Age: 1 Month – 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to evaluate the efficacy of rectal ozone therapy as a neuroprotective modality in Pediatric acquired brain injury.

Detailed description

Acquired brain injury (ABI) from primary neurologic diagnoses accounts for 20% of all pediatric critical care admissions and more than 60,000 hospital admissions annually. Ozone (O3) gas was discovered in the 1840s, and soon after that, the scientific community began to expand past the notion that it was just another gas of the Earth's atmosphere.

Conditions

• Rectal Ozone
• Neuroprotector
• CNS
• Insult
• Children

Interventions

Type	Name	Description
OTHER	Rectal ozone sessions	Patients will receive 40 Rectal ozone sessions or until improvement (maximum 80 sessions), in addition to their conventional rehabilitation program.
OTHER	Conventional rehabilitation program	Patients will receive their conventional rehabilitation program only (physiotherapy sessions three times per week for the treatment period (six months).

Timeline

• Start date: 2025-05-01
• Primary completion: 2025-10-01
• Completion: 2025-10-01
• First posted: 2025-09-04
• Last updated: 2025-09-04

Locations

1 site across 1 country: Egypt