NCT07153601

Norepinephrine vs. Phenylephrine for Spinal Hypotension in Cesarean Section

Comparison of the Effectiveness of Bolus Doses of Norepinephrine 4 mcg and Phenylephrine 50 mcg in Managing Hypotension After Spinal Anesthesia in Cesarean Section Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 46 (actual)
• Sponsor: Universitas Sumatera Utara · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This clinical trial was conducted to compare the effectiveness and safety of two medications-norepinephrine and phenylephrine-in treating low blood pressure (hypotension) that often occurs during spinal anesthesia for cesarean section (C-section) deliveries. Spinal anesthesia is commonly used during C-sections but can cause a drop in the mother's blood pressure, which may affect both the mother and the baby. In this study, 46 pregnant women undergoing elective C-sections were randomly given either norepinephrine (4 mcg) or phenylephrine (50 mcg) when their blood pressure dropped. Researchers monitored their heart rate, blood pressure, and any side effects for 30 minutes after anesthesia. The results showed that both drugs were effective in raising blood pressure. However, norepinephrine kept the heart rate more stable, while phenylephrine caused a noticeable slowing of the heart rate (bradycardia). Both drugs were safe and well tolerated. This study suggests that norepinephrine may be a better option for managing low blood pressure during spinal anesthesia in C-sections, especially when maintaining heart rate and cardiac output is important.

Conditions

• Hypotenstion
• Cesarean Resection
• Anesthesia Spinal
• Pregnancy Complications
• Cardiovascular

Interventions

Type	Name	Description
DRUG	Norepinephrine 4mcg	Norepinephrine 4 mcg IV bolus diluted in 2 mL normal saline, administered upon onset of hypotension during spinal anesthesia.
DRUG	Phenylephrine 50 mcg	Phenylephrine 50 mcg IV bolus diluted in 2 mL normal saline, administered upon onset of hypotension during spinal anesthesia.

Timeline

• Start date: 2025-02-07
• Primary completion: 2025-05-10
• Completion: 2025-05-10
• First posted: 2025-09-04
• Last updated: 2025-09-04

Locations

1 site across 1 country: Indonesia