NCT07151729

Use of Anodal tDCS to Enhance Upper Limb Recovery in Stroke

Use of Anodal Transcranial Direct Current Stimulation to Enhance Upper Limb Recovery in Stroke

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Tan Tock Seng Hospital · Academic / Other
• Sex: All
• Age: 21 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This will be a randomized, blinded, sham-controlled trial. The medical device used, Soterix Medical 1x1 tDCS stimulator, is capable of delivering either real or sham tDCS and has been used in many randomised controlled trials in stroke patients. 50 patients with subacute stroke and severe upper limb weakness within 8 weeks of stroke on transfer to TTSH stroke rehab wards will be recruited over a period of 10 months. Recruited patients will be randomized into the intervention and control arms in a 1:1 ratio.

Detailed description

The primary objective is to determine the clinical efficacy, technical feasibility and safety of anodal tDCS therapy to the unaffected hemisphere in hospitalized subacute stroke patients with severe arm weakness.

Conditions

• Stroke

Interventions

Type	Name	Description
DEVICE	Anodal tDCS	This anodal tDCS is applied over the contralateral dorsal premotor cortex (instead of the ipsilateral motor cortex in previous studies).
DEVICE	Sham tDCS	Sham tDCS is applied

Timeline

• Start date: 2025-09-01
• Primary completion: 2026-09-15
• Completion: 2026-12-31
• First posted: 2025-09-03
• Last updated: 2025-09-03

Locations

1 site across 1 country: Singapore

Regulatory

• FDA-regulated device study