NCT07151235

Wildfire Related Air Pollution Exposure and Cognitive Function Pilot Study

A Controlled Human Environmental Study Evaluating the Impacts of Cognitive Functions During the Exposure of Simulated Wildfire-Related Air Pollution (WRAP).

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Rutgers, The State University of New Jersey · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This study will examine how breathing wildfire-related air pollution (WRAP) for one hour affects healthy adults. The main question the study will answer if the effect of WRAP exposure on p-tau, a blood marker of cognitive decline. The changes in p-tau concentrations after exposure to WRAP will be compared to the changes in p-tau after exposure to clean air. Participants will: * Have 2 study visits - one visit with exposure to clean air and one visit with exposure to simulated wildfire smoke * Have blood drawn before and after each exposure * Complete cognitive tests and memory tasks before and after each exposure

Detailed description

* Exposures will take place in a booth-like exposure chamber (1 x 0.7 x 1.8 m) with glass upper panels. One person will be exposed at a time. * Simulated wildfire smoke will be generated by burning pine wood at a temperature that mimics smoldering combustion. The levels of smoke introduced into the exposure chamber are similar to those found during outdoor bonfires and wildfire events. The levels of particulate matter (PM) will be closely monitored during the exposure.

Conditions

• Healthy Participants

Interventions

Type	Name	Description
OTHER	Simulated wildfire smoke exposure	1 hour exposure to simulated wildfire smoke (300 ug/m3 PM)
OTHER	Clean Air exposure	1 hour exposure to clean (HEPA-filtered) air (0 ug/m3 PM)

Timeline

• Start date: 2025-09-18
• Primary completion: 2025-11-20
• Completion: 2025-11-20
• First posted: 2025-09-03
• Last updated: 2025-12-02

Locations

1 site across 1 country: United States