NCT07150169

Individualized Magnetic Stimulation for Post-stroke Cognitive Recovery: Optimization, Validation & Efficacy

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (estimated)
• Sponsor: Jord Vink · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Rationale: 75% of all stroke survivors suffer from cognitive deficits in the acute phase, with serious implications for their long-term quality of life and societal participation. A promising novel therapy is repetitive transcranial magnetic stimulation (rTMS). Only a handful of studies have attempted to promote cognitive functioning after stroke with rTMS. These studies exclusively used a one-size-fits-all approach, which had limited success, as post-stroke cognitive deficits are highly variable. We propose a two-step personalized treatment strategy to identify targets for therapeutic TMS for cognitive rehabilitation after stroke. Step one consits of identification of personalized TMS targets by measuring fMRI activity during a representative cognitive task. In step two, TMS disruption is used to temporarily disrupt activity in the targeted brain region to investigate causal involvement of a brain area in cognitive task performance. Objective: To validate a proof-of-concept to identify personalized targets for therapeutic TMS for cognitive rehabilitation after stroke. Study design: A prospective mechanistic intervention study. Study population: 10 healthy individuals and 15 stroke patients with cognitive impairment Intervention: Active and sham TMS disruption of personalized targets Main study endpoints: The n-back test

Conditions

• Stroke

Interventions

Type	Name	Description
DEVICE	Active TMS disruption	Active TMS disruption delivered to the personalized target
DEVICE	Sham TMS disruption	Sham TMS disruption delivered to the personalized target

Timeline

• Start date: 2025-11-01
• Primary completion: 2027-10-01
• Completion: 2027-11-01
• First posted: 2025-09-02
• Last updated: 2025-09-02