NCT07149272

Lactate Kinetics Analysis Related to Low-Intensity Resistance Exercise

Lactate Kinetics Analysis Related to Low-Intensity Resistance Exercise: Randomized Control Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Dr Cipto Mangunkusumo General Hospital · Academic / Other
• Sex: All
• Age: 60 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The goal of this study aims to analyze lactate kinetics as an exercise response after conventional multimodal exercise and virtual reality exercise (VRE) in hospitalized geriatric. The main question it aims to answer are: 1. are there any difference in post exercise lactate at day 1 and 7 between the two groups? 2. does the lactate concentration reduces after low intensity resistance exercise in subject with high resting lactate? Participants were randomized into control and VRE group. Peripheral blood lactate was taken immediately before and after low-intensity resistance exercise at baseline and one week after

Detailed description

Sixty geriatric patients were recruited during their hospitalization at RSUPN Dr. Cipto Mangunkusumo (RSCM). Subjects were randomized into control and intervention group. Both groups get conventional multimodal exercise, the intervention group gets additional VRE as adjuvant therapy. Exercise prescription was given after the subjects going through functional assessment conducted by physiatrists. The prescription described the frequency, intensity, interval, and type of exercise that is adjusted to subject's clinical condition. Each subject could have more than one type of exercise, but the most common combination consists of breathing, resistance, and aerobic exercises. VRAGMENT software was administered as VRE to the intervention group. In VRAGMENT, subjects should make phone call, groceries and making payment. Those activities in virtual environment initiated real movement of neck, trunk, arms, and legs. Capillary blood lactate sample was examined using StatStrip® from Nova Biomedical. Measurement range of StatStrip® is 0,3 - 20,0 mmol/L. Lactate examination conducts at baseline and one week after the exercise program. Blood samples were collected immediately pre and post-standardized low-intensity resistance training. The data collected were analyzed using SPSS statistics (version 24.0).

Conditions

• Fatigue
• Lactate

Interventions

Type	Name	Description
DEVICE	Virtual Reality Exercise (VRE) using VRAGMENT software	Adjuvant Virtual Reality Exercise (VRE) delivered via Oculus Quest 2 headset with VRAGMENT software, a culturally adapted VR program simulating daily activities (e.g., grocery shopping, phone calls) to induce physical movement. Participants received VRE alongside conventional multimodal exercise (breathing, resistance, aerobic) during hospitalization. Sessions were tailored to individual clinical conditions and aimed to improve fatigue and mobility through gamified rehabilitation

Timeline

• Start date: 2024-02-16
• Primary completion: 2025-05-30
• Completion: 2025-05-30
• First posted: 2025-08-29
• Last updated: 2025-08-29

Locations

1 site across 1 country: Indonesia