NCT07148102

Diaphragmatic Ultrasound and Thoracic Fluid Content for Prediction of Non-Invasive Ventilation Failure in Neonates

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 90 (actual)
• Sponsor: Lamiaa Khaled Zidan · Academic / Other
• Sex: All
• Age: 30 Minutes – 30 Minutes
• Healthy volunteers: Not accepted

Summary

This research assessed diaphragmatic ultrasound and thoracic fluid content (TFC) as potential early predictive tools for detecting NIV failure in preterm neonates.

Detailed description

Non-invasive ventilatory support (NIV) is considered a gold standard care for preterm infants with respiratory distress syndrome (RDS); however, NIV failure remains a frequent challenge that is often associated with many adverse outcomes

Conditions

• Diaphragm Ultrasound
• Electrical Cardiometry
• Non Invasive Ventilation (NIV)
• RDS of Prematurity

Interventions

Type	Name	Description
DEVICE	Diaphragmatic US	Diaphragmatic thickening fraction (DTF) and diaphragmatic excursion (DE) were measured by ultrasound within the first three hours of life and repeated either 24 hours later in successful cases or immediately before intubation in cases who had NIV failure.
DEVICE	EC	TFC was assessed using electrical cardiometry (EC). Measurements were obtained within the first three hours of life and repeated either 24 hours later in successful cases or immediately before intubation in cases who had NIV failure.

Timeline

• Start date: 2020-05-01
• Primary completion: 2023-05-01
• Completion: 2023-05-01
• First posted: 2025-08-29
• Last updated: 2025-08-29

Locations

1 site across 1 country: Egypt