NCT07148063

Inflammatory Biomarkers as Predictors of PONV Following Pediatric Orchiopexy

Association of Preoperative Inflammatory Biomarkers With Postoperative Nausea and Vomiting in Children Undergoing Orchiopexy

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 170 (estimated)
• Sponsor: Diskapi Yildirim Beyazit Education and Research Hospital · Other Government
• Sex: All
• Age: 1 Year – 8 Years
• Healthy volunteers: Not accepted

Summary

Orchiopexy is a common surgical procedure for the treatment of cryptorchidism in the pediatric population, with a high incidence of postoperative nausea and vomiting (PONV). Recent evidence suggests that systemic inflammation may contribute to PONV pathogenesis, and preoperative inflammatory biomarkers such as NLR, PLR, SII, MLR, and SIRI could serve as predictive indicators. This prospective observational study aims to evaluate the relationship between these biomarkers and PONV incidence in children undergoing orchiopexy.

Conditions

• Pediatric Anesthesia
• Postoperative Nausea and Vomiting (PONV)
• Inflammatory Biomarkers

Interventions

Type	Name	Description
OTHER	Measurement of Preoperative Inflammatory Biomarkers	Blood samples will be collected preoperatively to measure inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index, monocyte-to-lymphocyte ratio (MLR), and systemic inflammation response index. These values will be analysed in relation to the incidence of postoperative nausea and vomiting within the first 6 hours after pediatric orchiopexy. No experimental drug or device will be administered as part of the study; all procedures will be conducted within the scope of standard perioperative care.

Timeline

• Start date: 2025-09-08
• Primary completion: 2026-03-13
• Completion: 2026-03-27
• First posted: 2025-08-29
• Last updated: 2025-09-09

Locations

1 site across 1 country: Turkey (Türkiye)