NCT07147842

Rutin Therapy Role in Reducing Ulcerative Colitis Severity

Rutin Therapy Reduces Ulcerative Colitis Disease Activity By Inhibiting The NOD-Like Receptor Protein 3 (NLRP3) Inflammasome: A Molecular Assessment in a Case-Control Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Benha University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Ulcerative colitis (UC) is an inflammatory bowel disease characterized by oxidative stress and recurring inflammation in the colon. The condition can become chronic, spread, and lead to other complications. A key player in the inflammation process is the NLRP3 inflammasome. This inflammasome's expression is heightened and activated by reactive oxygen species (ROS). Its activity is influenced by various factors, including the ubiquitin system, ion channels, and gut microbiota. Rutin, a compound found in many fruits and vegetables, has been shown to have properties that help scavenge free radicals.

Conditions

• Ulcerative Colitis

Interventions

Type	Name	Description
DRUG	Rutin 500 MG	Rutin 500 mg capsules twice daily for 30 days
OTHER	Placebo	Placebo Tablets
DIAGNOSTIC_TEST	fecal calprotectin	Fecal calprotectin level was measured using an ELISA kit .

Timeline

• Start date: 2024-11-01
• Primary completion: 2025-01-08
• Completion: 2025-05-20
• First posted: 2025-08-29
• Last updated: 2025-08-29

Locations

1 site across 1 country: Egypt