NCT07147595

Chronic Effect of Isometric Exercise on Blood Pressure in Patients With Hypertension

Chronic Effect of Isometric Exercise on Blood Pressure in Patients With Controlled Hypertension: a Randomized Clinical Trail

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 66 (actual)
• Sponsor: Instituto de Cardiologia do Rio Grande do Sul · Academic / Other
• Sex: All
• Age: 40 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

International recommendations support dynamic or isometric strength training as an adjunct to aerobic exercise. Given the lack of consensus, this study aims to evaluate the chronic effects of isometric exercise, performed through handgrip or isometric knee extension, as a hypotensive strategy in adults with hypertension.

Detailed description

This study is designed as a randomized, controlled, evaluator-blinded clinical trial, conducted entirely at the Laboratory of Clinical Investigation (LCI) of the Cardiology Institute of Rio Grande do Sul / University Foundation of Cardiology (ICFUC). The project follows all recommendations of the CONSORT Statement. Male and female participants aged 40 to 70 years, with blood pressure ≥ 120/80 mmHg, will be enrolled. After signing informed consent, participants will complete a questionnaire to assess their habitual physical activity level and will undergo isometric handgrip or isometric knee extension training for 4 weeks. Blood pressure will be assessed at baseline and after the intervention using ambulatory blood pressure monitoring (ABPM).

Conditions

• Hypertension (HTN)
• Hypertension Arterial

Interventions

Type	Name	Description
PROCEDURE	Isometric handgrip exercise	Participants will train 3 times per week for 4 weeks. Each session will consist of four sets of 2-minute contractions sustained at 30% of maximum voluntary contraction (MVC), performed with a handgrip device for each arm, with 1-minute rest intervals between sets and between arms.
PROCEDURE	Isometric knee extension exercise	Participants will train 3 times per week for 4 weeks. Each session will consist of four sets of 2-minute contractions sustained at 30% of maximum voluntary contraction (MVC), performed with adjustable ankle weights for each leg, with 1-minute rest intervals between sets and between legs.

Timeline

• Start date: 2023-08-31
• Primary completion: 2023-09-01
• Completion: 2025-02-28
• First posted: 2025-08-29
• Last updated: 2025-08-29

Locations

1 site across 1 country: Brazil