NCT07147179

Short Course Radiotherapy

Pilot Trial of Short Course Radiotherapy for Primary or Secondary CNS Malignancies

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (estimated)
• Sponsor: Abramson Cancer Center at Penn Medicine · Academic / Other
• Sex: All
• Age: 21 Years
• Healthy volunteers: Not accepted

Summary

This is a single arm prospective pilot trial determining the safety of short-course radiation therapy in pediatric patients with incurable central nervous system malignancies.

Detailed description

Participants will receive a shorter course of radiation therapy across 5 days (20 Gray in 5 fractions) in contrast to the standard treatment of two weeks or more of daily treatments (up to 3 Gray per day). This research study is being conducted to see if delivering a shorter course of radiation therapy is safe and helps quality of life so that it may reduce the required duration of palliative treatment.

Conditions

• Central Nervous System Cancer

Interventions

Type	Name	Description
RADIATION	Short Course Radiotherapy	Participants will receive a shorter course of radiation therapy across 5 days (20 Gray in 5 fractions).

Timeline

• Start date: 2026-02-01
• Primary completion: 2027-03-01
• Completion: 2027-03-01
• First posted: 2025-08-29
• Last updated: 2026-01-22

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study