NCT07146685

Effect of Local Anesthetic Concentration on Rebound Pain: A Randomized Control Study

• Status: Not Yet Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 168 (estimated)
• Sponsor: University of Virginia · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Randomized control study that compares different concentrations of local anesthetic to investigate whether a lower concentration of local anesthetic would contribute to lower rebound pain scores at 24 hours post op in patients undergoing anatomic or reverse total shoulder arthroplasty.

Conditions

• Rebound Pain
• Shoulder Arthroplasty
• Interscalene Block

Interventions

Type	Name	Description
DRUG	Bupivacaine	We are comparing two concentrations of the same drug: 10 ml of 0.5% and 20 ml of 0.25%; We will use the same milligram dose (50 mg).

Timeline

• Start date: 2026-01-01
• Primary completion: 2028-01-01
• Completion: 2029-01-01
• First posted: 2025-08-28
• Last updated: 2025-08-28

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study