NCT07146308

Multi-omics Mechanisms of Lifestyle Intervention in Regulating Blood Glucose

Multiscale Causal Disease Warning and Assisted Diagnosis: Multi-omics Mechanisms of Lifestyle Intervention in Regulating Blood Glucose

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 61 (actual)
• Sponsor: Shanghai 6th People's Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The mechanisms by which lifestyle interventions regulate blood glucose remain incompletely understood. Traditional research has predominantly focused on single targets or pathways, making it difficult to comprehensively elucidate the complex biological regulatory networks. This study systematically investigates the effects of lifestyle interventions on blood glucose and explores their molecular mechanisms. Through integrated multi-omics analysis-including genomics, proteomics, metabolomics, and microbiomics-investigators aim to identify key biological pathways and molecular targets through which dietary, exercise, and other lifestyle interventions influence glucose regulation, as well as discover biomarkers that reflect the efficacy of these interventions. Building upon these findings, investigators will establish a multi-omics molecular network model linking lifestyle interventions to glucose regulation and develop an auxiliary decision-making system for personalised diabetes diagnosis and treatment.

Conditions

• Diabetes

Interventions

Type	Name	Description
OTHER	Lifestyle Management	Participants will undergo dietary and exercise interventions. The dietary intervention includes breakfast, lunch, and dinner, while the exercise intervention consists of both aerobic and resistance training.

Timeline

• Start date: 2025-08-31
• Primary completion: 2025-09-30
• Completion: 2025-10-30
• First posted: 2025-08-28
• Last updated: 2025-11-25

Locations

1 site across 1 country: China