NCT07145879

Comparison of Postoperative Effects of Articaine and Lidocaine in Mucogingival Surgery

Differences in Soft Tissue Healing and Vascularization Between Articaine and Lidocaine: A Randomized Clinical and Ultrasonographic Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 43 (actual)
• Sponsor: Pamukkale University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to compare and evaluate the effects of using lidocaine 2% (with adrenaline) and articaine 4% (with adrenaline) in free gingival graft (FGG) surgery on postoperative wound healing, changes in blood flow in the surgical area during the healing process, patients' postoperative pain levels, and anxiety levels before and after surgery.

Detailed description

In a prospective randomised controlled trial conducted to investigate the effect of lidocaine and articaine on postoperative free gingival graft healing, wound healing was assessed using EHS, anxiety was assessed using VAS, STAI, and MDAS questionnaires, and ultrasonographic evaluations and PI measurements were used to determine whether there was a difference in wound healing between the two anaesthetics.

Conditions

• Local Analgesia Via Infiltration
• Wound Heal
• Pain, Postoperative
• Hemorrhage

Interventions

Type	Name	Description
DRUG	Lidocaine hydrochloride 2% with epinephrine 1:100 000	Patient were received infiltrative anesthesia with Lidocaine (Jetokain, Adeka Ilaç, Samsun, Türkiye): Active ingredient: Each 1 ml contains 20 mg lidocaine hydrochloride (HCL) and 0.012 mg epinephrine base. Excipients: Sodium metabisulfite, sodium chloride, water for injection.
DRUG	Articaine 4% with epinephrine 1:100,000	Patients were received Infiltrative anesthesia with Articaine (Ultracain DS Forte, Sanofi Aventis İlaçları, Istanbul, Türkiye): Active ingredient: 40 mg articaine HCL and 0.012 mg epinephrine per 1 ml. Excipients: Sodium chloride, sodium metabisulfite, hydrochloric acid, water for injection
PROCEDURE	Free gingival graft (FGG)	FGG surgery was performed around natural teeth and implants where keratinized gingival tissue was inadequate.

Timeline

• Start date: 2025-01-01
• Primary completion: 2025-07-30
• Completion: 2025-07-30
• First posted: 2025-08-28
• Last updated: 2025-08-28

Locations

1 site across 1 country: Turkey (Türkiye)