NCT07144215

ED50 of Dexmedetomidine as an Adjuvant to 0.5% Hyperbaric Bupivacaine 12.5 mg for Spinal Anesthesia in Hip and Knee Surgery: An Up-and-Down Method Approach

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Indonesia University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Determine ED50 dexmedetomidine adjuvant that can provide spinal anesthetic sensory blockade duration of 200 minutes on knee and pelvis surgery with up-and-down method.

Conditions

• Knee Surgery
• Pelvic Surgery
• Spinal Aneshtesia

Interventions

Type	Name	Description
DRUG	Dexmedetomidine 3 mcg	Patient received spinal injection of dexmedetomidine 3 mcg.
DRUG	Dexmedetomidine 4 mcg	Patient received spinal injection of dexmedetomidine 4 mcg.
DRUG	Dexmedetomidine 5 mcg	Patient received spinal injection of dexmedetomidine 5 mcg.
DRUG	Dexmedetomidine 6 mcg	Patient received spinal injection of dexmedetomidine 6 mcg.
DRUG	Bupivacain hyperbaric 0.5% 12.5 mg	Patient received spinal injection of Bupivacain hyperbaric 0.5% 12.5 mg

Timeline

• Start date: 2025-02-01
• Primary completion: 2025-05-31
• Completion: 2025-05-31
• First posted: 2025-08-27
• Last updated: 2025-09-05

Locations

1 site across 1 country: Indonesia