NCT07143747

PAXT: Pulmonary Imaging of Mild Asthma Using 129Xe MRI and Tc-99-Labeled-Carbon-Imaging (Tc99CImaging)

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: Dr. Grace Parraga · Academic / Other
• Sex: All
• Age: 17 Years – 35 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to better understand how asthma affects the lungs in young adults (ages 17-35) with mild asthma. The main questions it aims to answer are: * Can advanced imaging detect abnormal airway function in people with mild asthma? * Do changes in ventilation imaging correlate with asthma symptoms or quality of life? Researchers will compare hyperpolarized xenon-129 MRI and Technegas (Tc-99m) imaging to see if these techniques reveal more detailed lung abnormalities than standard lung function tests. Participants will: * Complete a single 2-hour visit * Undergo two types of lung imaging: Hyperpolarized xenon-129 MRI (to visualize how air moves in the lungs), Technegas (Tc-99m) imaging (to assess airflow using nuclear medicine) * Perform spirometry and other breathing tests * Answer questionnaires about asthma symptoms and quality of life This study is designed to improve our understanding of subtle changes in lung function that may not be detected by standard tests in people with mild asthma. The findings may lead to better diagnostic tools and more personalized treatment strategies in the future.

Detailed description

This is a single centre, study in university-aged participants diagnosed with mild asthma as indicated by a prescription for a short acting bronchodilator for use as needed. Each participant will participate in one research study visit which includes pre- and post- bronchodilator (BD) spirometry, plethysmography, oscillometry, 129Xe MRI as well as pre-BD ultra-low dose chest CT, Tc99CImaging, blood CBC, sputum induction, as well as completion of the ACQ and AQLQ questionnaires.

Conditions

• Mild Asthma

Interventions

Type	Name	Description
OTHER	Hyperpolarized 129Xe MRI	Inhalation of hyperpolarized 129Xe gas followed by breath-hold MRI for ventilation imaging.
OTHER	Tc-99m Technegas Ventilation Imaging	Inhalation of Tc-99m-labeled carbon aerosol (Technegas) followed by SPECT imaging to assess lung ventilation.

Timeline

• Start date: 2025-09-01
• Primary completion: 2028-08-01
• Completion: 2028-12-01
• First posted: 2025-08-27
• Last updated: 2025-08-27

Locations

1 site across 1 country: Canada