NCT07143695

Parasternal Intercostal Muscle Thickening as an Additive Weaning Criterion

Parasternal Intercostal Muscle Thickening as an Additive Weaning Criterion to Minimize Re-intubation Rate: a Randomized Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Increased days of MV are not without hazards, including barotraumas and ventilator-associated pneumonia. Similarly, premature separation of MV is associated with increased mortality secondary to adverse cardiorespiratory events. Therefore, the time of weaning should be wisely evaluated. There is growing evidence concerning respiratory muscles dysfunction that contributes to difficulty or prolonged liberation from MV.

Detailed description

Researchers aim to evaluate the influence of adding parasternal thickening fraction to the standard weaning criteria and its impact on reintubation

Conditions

• Critically Ill

Interventions

Type	Name	Description
DEVICE	Parasternal intercostal thickening fraction	Parasternal intercostal thickening fraction less than 6.5%
DEVICE	Sham parasternal intercostal thickening	Ultrasound assessment only for purpose of blinding

Timeline

• Start date: 2025-09-01
• Primary completion: 2026-08-01
• Completion: 2026-08-31
• First posted: 2025-08-27
• Last updated: 2025-09-08

Locations

1 site across 1 country: Egypt