NCT07143305

Effect of Citrulline Malate Supplementation on Physical Function and Biochemical Parameters in Physically Active Older Women

Effect of Citrulline Malate Supplementation During a Multicomponent Exercise Program on Physical Function and Biochemical Parameters in Physically Active Older Women: a Randomised Controlled Pilot Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Universidad de Burgos · Academic / Other
• Sex: Female
• Age: 60 Years – 75 Years
• Healthy volunteers: Accepted

Summary

A randomised, double-blind, placebo-controlled pilot trial was conducted with thirty-three community-dwelling women aged 65 years or over. Participants were assigned to a multicomponent training programme (three days per week) and received either 3 g per day of citrulline malate or a placebo. Assessments were conducted before and after the intervention, including tests of physical performance (6MWT, sit-to-stand, SPPB), blood biomarkers (vitamin D, glucose, CK, hormones), and perceived quality of life (WHOQOL-BREF).

Conditions

• Supplementation

Interventions

Type	Name	Description
OTHER	Multicomponent physical exercise programme	Participants engaged in a multicomponent physical exercise programme designed specifically for older adults. The programme was based on the latest evidence and international recommendations for sarcopenia and functional maintenance in ageing population.

Timeline

• Start date: 2020-03-15
• Primary completion: 2020-04-15
• Completion: 2020-05-15
• First posted: 2025-08-27
• Last updated: 2025-10-02

Locations

1 site across 1 country: Spain