NCT07142941

Exercise and/or HMB in Older Diabetes With Low Muscle Mass

Effects of Exercise and/or β-hydroxy-β-methylbutyrate Supplementation on Muscle Mass, Physical Performance and Insulin Resistance in Older Diabetes With Low Muscle Mass: a Randomized, Double-blind, Placebo-controlled Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Wu Shangling · Academic / Other
• Sex: All
• Age: 60 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The investigators aimed to examine if β-hydroxy-β-methylbutyrate (HMB) supplementation enhances the effects of exercise on muscle mass, physical performance and insulin resistance and observe potential residual effects in older diabetes with low muscle mass, and to find the optimal treatment plan.

Detailed description

The interaction between exercise and nutritional supplementation is unclear among older diabetes at risk of sarcopenia. The investigators aimed to examine if β-hydroxy-β-methylbutyrate (HMB) supplementation enhances the effects of exercise on muscle mass, physical performance and insulin resistance and observe potential residual effects in older diabetes with low muscle mass, and to find the optimal treatment plan. This 12-wk, randomized, double-blind, placebo controlled, 2 × 2 factorial design (exercise-only, HMB-only, both, and none) trial included 120 older diabetes aged 60-80 y with skeletal muscle index \<5.7 kg/m2 for women, and \<7.0 kg/m2 for men, and was followed by a 12-wk observational period.

Conditions

• Diabetes
• Low Muscle Mass

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	HMB	Participants were instructed to take active products including 3000 mg calcium-HMB per day
BEHAVIORAL	Exercise	Participants allocated to the exercise programs were provided 45 min of supervised sessions on 2 nonconsecutive days per week
DIETARY_SUPPLEMENT	Placebo	Participants were instructed to take active products including equal in quality resistant dextrin per day
OTHER	Education	Participants were given health education and educational manuals

Timeline

• Start date: 2026-04-01
• Primary completion: 2027-12-31
• Completion: 2027-12-31
• First posted: 2025-08-27
• Last updated: 2026-03-31