NCT07142369

Synovial Fluid Withdrawal or PRP Injection For Acute ACL Tears and Cytokines

Does Arthrocentesis and PRP For Acute ACL Tears With Hemarthrosis Decrease Inflammatory Cytokines At Time Of Surgery: A Prospective Randomized Control Trial (RCT)

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 99 (estimated)
• Sponsor: Rush University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine what effects the withdrawal of excess knee joint fluid or the injection of a factor from the blood has on swelling after a sudden anterior cruciate ligament (ACL) rupture of the knee.

Detailed description

The body responds to different stresses by releasing factors in the blood and fluids in response to stressors like injury, surgery or certain treatments. Some of these factors help heal and some make the injury and body swell (inflammation). In this study we want to see if the intervention of withdrawing fluid the knee or the addition of an enriched healing factor called platelet rich plasma (PRP) injected in the knee influences the body to produce healing factors in the knee joint fluid.

Conditions

• Posttraumatic Osteoarthritis
• Anterior Cruciate Ligament (ACL) Rupture

Interventions

Type	Name	Description
PROCEDURE	Synovial Fluid withdrawal at the preoperative clinic visit	Synovial Fluid withdrawal at the preoperative clinic visit
PROCEDURE	Platelet-Rich Plasma (PRP) preparation and injection	Platelet-Rich Plasma (PRP) preparation and injection
PROCEDURE	Synovial fluid withdrawal at the time of surgery	Synovial fluid withdrawal at the time of surgery
PROCEDURE	3mL synovial fluid withdrawn at the preoperative visit	3mL synovial fluid withdrawn at the preoperative visit

Timeline

• Start date: 2026-05-01
• Primary completion: 2028-10-01
• Completion: 2028-12-01
• First posted: 2025-08-26
• Last updated: 2026-02-12

Locations

1 site across 1 country: United States