NCT07141888

The Effects of a Probiotic Food Supplement in Hyperuricaemia

The Effects of a Novel Probiotic Food Supplement in Hyperuricaemia - Towards Development of an Individualised Treatment Strategy

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 99 (estimated)
• Sponsor: Örebro University, Sweden · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The overall aim of the project is to determine whether a daily intake of health-promoting bacteria, known as probiotics, with or without a dietary fiber, affects uric acid levels in individuals with elevated levels of uric acid in the blood (hyperuricemia). Additionally, the project will investigate which individuals benefit from this dietary supplement and which do not, based on factors such as gut microbiota composition and function, dietary habits, genetic factors, and inflammatory status. The ultimate goal is to develop a personalized therapy for hyperuricemia. At the beginning of the study, blood samples will be taken to determine uric acid levels and 99 individuals with hyperuricemia will be invited to participate in a 6-week intervention study with daily intake of dietary supplements. To examine the effect of the supplement on various health variables, blood, urine, stool, and breath samples will be collected on several occasions. To better understand the underlying factors of hyperuricemia, questionnaire data and results from biological will be compared between participants with normal versus elevated uric acid levels. Furthermore, different outcome parameters from questionnaires and samples before and after supplement intake will be compared. In addition, various methods for estimating dietary intake will be investigated and compared with each other.

Conditions

• Hyperuricemia With or Without Gout

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Placebo (no active ingredient)	Placebo product containing the same ingredients as the active intervention but without the active compounds
DIETARY_SUPPLEMENT	Probiotics	Product contains two probiotic strains
DIETARY_SUPPLEMENT	Probiotics plus fibre	Product contains two probiotic strains plus a fibre (beta-glucan)

Timeline

• Start date: 2025-12-16
• Primary completion: 2026-12-01
• Completion: 2027-12-01
• First posted: 2025-08-26
• Last updated: 2026-03-27

Locations

1 site across 1 country: Sweden