NCT07141524

Optimizing Breathing and Blood Flow in Patients Treated With VA ECMO

Ventilation-Perfusion Matching and PEEP Titration in Patients Undergoing Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation (VA ECMO)

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: Beth Israel Deaconess Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to characterize ventilation/perfusion (V/Q) matching in adult patients receiving peripheral VA ECMO support while on mechanical ventilation, and to evaluate the impact of PEEP titration guided by Electrical Impedance Tomography (EIT) and esophageal pressure measurements on lung mechanics and V/Q optimization.

Detailed description

The investigators hypothesize that an individualized PEEP titration guided by esophageal pressure measurements and Electrical Impedance Tomography can reduce lung overdistention, enhance lung recruitment, and improve V/Q matching by optimizing regional ventilation and perfusion also in VA ECMO. Our objectives are: 1. To describe V/Q matching in patients undergoing mechanical ventilation during peripheral VA ECMO support. 2. To explore the impact of PEEP titration based on esophageal pressure and EIT in terms of lung mechanics and V/Q matching.

Conditions

• VA-ECMO

Interventions

Type	Name	Description
OTHER	Physiology measurements	Measurement of lung perfusion (via EIT) and transpulmonary pressure (via esophageal manometry) during decremental PEEP trial

Timeline

• Start date: 2026-01-27
• Primary completion: 2026-12-31
• Completion: 2027-02-28
• First posted: 2025-08-26
• Last updated: 2026-02-02

Locations

2 sites across 1 country: United States