NCT07140510

Dinalbuphine Sebacate in Postoperative Pain Control After TKA

Effectiveness of Dinalbuphine Sebacate in Postoperative Pain Control Following Total Knee Arthroplasty: A Randomized Double Blinded Placebo-controlled Trial

• Status: Not Yet Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Thammasat University · Academic / Other
• Sex: All
• Age: 50 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

To evaluate the effectiveness of Dinalbuphine Sebacate for controlling subacute pain after total knee arthroplasty

Detailed description

A single dose of intramuscular Dinalbuphine Sebacate can mitigate pain for up to 1 week after TKA

Conditions

• Osteo Arthritis of the Knee
• Total Knee Anthroplasty

Interventions

Type	Name	Description
DRUG	Dinalbuphine Sebacate	Dinalbuphine Sebacate 150 mg intramuscular injection after spinal anesthesia and adductor canal block in the same side of TKA
DRUG	Normal Saline	Normal saline 2 mL intramuscular injection after spinal anesthesia and adddutor canal block

Timeline

• Start date: 2025-10-01
• Primary completion: 2026-06-01
• Completion: 2026-09-01
• First posted: 2025-08-24
• Last updated: 2025-08-24

Locations

1 site across 1 country: Thailand