NCT07139301

Timing of Anticoagulation After Emergency Endovascular Therapy for Acute Ischemic Stroke With Atrial Fibrillation

Timing of Anticoagulation After Emergency Endovascular Therapy for Acute Ischemic Stroke With Atrial Fibrillation：a Randomised Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 438 (estimated)
• Sponsor: Capital Medical University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study evaluates the safety and efficacy of early versus delayed initiation of direct oral anticoagulants (DOACs) in patients with acute ischemic stroke related to atrial fibrillation after emergency endovascular therapy (EVT).

Detailed description

This is a multicenter, prospective, open-label, randomized controlled trial evaluating the safety and efficacy of different initiation timings of direct oral anticoagulants (DOACs) therapy in patients with acute ischemic stroke related to atrial fibrillation after emergency endovascular therapy (EVT).

Conditions

• Ischemic Stroke
• Atrial Fibrillation

Interventions

Type	Name	Description
DRUG	Early anticoagulation	Early initiation of direct oral anticoagulants will be started within four days after symptom onset.
DRUG	Delayed anticoagulation	Delayed initiation of direct oral anticoagulants will be started between 5-14 days after symptom onset.

Timeline

• Start date: 2025-09-04
• Primary completion: 2026-08-31
• Completion: 2026-08-31
• First posted: 2025-08-24
• Last updated: 2026-02-05

Locations

40 sites across 1 country: China