NCT07138443

Influence of Melatonin on Cardiovascular and Thermoregulatory Responses to Stress

Influence of Melatonin on Cardiovascular and Skin Temperature Responses to Stress: A Randomized Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Baylor University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

This study aims to evaluate the influence of acute oral melatonin supplementation on cardiovascular and skin temperature responses to mental stress. The hypothesis is that acute melatonin will lead to reduced cardiovascular and skin temperature responsiveness to acute mental stress.

Detailed description

This study will utilize a randomized, crossover, placebo controlled experimental approach to determine the effects of acute oral melatonin supplementation (3mg) on blood pressure, heart rate, and regionalized skin temperature responsiveness to mental stress. The study will assess beat-by-beat blood pressure (finger plethysmography), continuous heart rate (electrocardiogram), and proximal/distal skin temperature continuously at rest and in response to the Trier Social Stress Test following either afternoon melatonin or placebo ingestion in a randomized order. Participants will consist of young healthy adults.

Conditions

• Stress
• Mental Stress

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Melatonin 3 MG Oral Tablet	Participants will ingest an acute 3mg oral melatonin tablet
DIETARY_SUPPLEMENT	Placebo Oral Tablet	Participants will ingest a placebo tablet (sugar pill) of the same size, shape, and color of the active melatonin supplement

Timeline

• Start date: 2025-08-01
• Primary completion: 2026-08-01
• Completion: 2026-08-01
• First posted: 2025-08-22
• Last updated: 2025-08-22

Locations

1 site across 1 country: United States