NCT07137013

Periodontitis Severity in Patients With Diabetic Retinopathy

Evaluation of the Relationship Between Periodontal Disease Severity and Retinal Layer Thickness in Patients With Diabetic Retinopathy Using Optical Coherence Tomography

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 100 (actual)
• Sponsor: Recep Tayyip Erdogan University Training and Research Hospital · Academic / Other
• Sex: All
• Age: 60 Years – 85 Years
• Healthy volunteers: Accepted

Summary

The aim of this observational study is to investigate the relationship between periodontal disease severity and retinal layer thickness in patients diagnosed with diabetic retinopathy (DR), using optical coherence tomography (OCT) for assessment. The main question this study seeks to answer is: Do measurable changes in retinal layer thickness occur as periodontal disease severity increases in patients with diabetic retinopathy? Participants will include adult individuals with a confirmed clinical diagnosis of DR. Periodontal status will be assessed through standard clinical parameters, including plaque index, probing pocket depth, clinical attachment loss, and bleeding on probing. Retinal layer thickness will be measured using high-resolution OCT and OCT angiography (OCTA) devices. The study aims to analyze potential associations between periodontal disease severity and morphological as well as vascular changes in the retina.

Detailed description

This observational study will aim to evaluate the possible relationship between periodontal disease severity and retinal layer thickness in patients with diabetic retinopathy (DR). Adult individuals with a confirmed clinical diagnosis of DR will be included in the study. Periodontal health status will be assessed using standard clinical parameters such as plaque index, probing pocket depth, clinical attachment loss, and bleeding on probing. Retinal layer thickness will be measured using high-resolution imaging with optical coherence tomography (OCT). Optical coherence tomography angiography (OCTA) will be used to evaluate vascular changes. The collected data will be analyzed to determine whether periodontal disease severity is associated with possible changes in retinal morphology and vascularity. This study is expected to provide new scientific evidence on the interaction between systemic diabetic complications and oral health, as well as to highlight the importance of multidisciplinary approaches.

Conditions

• Diabetic Retinopathy
• Periodontitis

Timeline

• Start date: 2025-02-24
• Primary completion: 2025-05-12
• Completion: 2025-06-23
• First posted: 2025-08-22
• Last updated: 2025-08-22

Locations

1 site across 1 country: Turkey (Türkiye)