NCT07135089

Improving Neuroprotective Strategy for Ischemic Stroke Before Endovascular Thrombectomy by Intravenous Tirofiban

Improving Neuroprotective Strategy for Ischemic Stroke Before Endovascular Thrombectomy by Intravenous Tirofiban (INSIST-IT2): a Prospective, Randomized, Double Blinded, Multi-center Study

• Status: Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 870 (estimated)
• Sponsor: General Hospital of Shenyang Military Region · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

It remains uncertain whether intravenous tirofiban administered before endovascular thrombectomy could improve disability severity for patients with LVO due to intracranial atherosclerosis.The current study aimed to assess the efficacy and safety of administering intravenous tirofiban before endovascular thrombectomy for improving clinical outcomes in patients with anterior circulation LVO due to intracranial atherosclerosis.

Conditions

• Stroke, Ischemic

Interventions

Type	Name	Description
DRUG	Intravenous tirofiban before endovascular thrombectomy	The tirofiban was administrated as a bolus dose of 10 μg/kg, followed by continuous infusion of 0.15 μg/kg/min for up to 24 hours.
DRUG	Intravenous placebo before endovascular thrombectomy	The placebo was administrated as a bolus dose of 10 μg/kg, followed by continuous infusion of 0.15 μg/kg/min for up to 24 hours.

Timeline

• Start date: 2025-11-13
• Primary completion: 2027-09-30
• Completion: 2027-12-30
• First posted: 2025-08-21
• Last updated: 2025-12-09

Locations

1 site across 1 country: China