NCT07133711

Noninvasive Ventilation Weaning Protocol in COPD

Impact of Noninvasive Ventilation Weaning Protocol on Outcome of Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Noninvasive ventilation (NIV) has revolutionized the management of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with hypercapnic respiratory failure (HcRF). NIV use has been shown to reduce the need for endotracheal intubation, hospital and intensive care unit (ICU) length of stay, and mortality. Multiple studies have been conducted on weaning strategies among patients requiring invasive mechanical ventilation. As a result of these studies, definite criteria and protocols have been laid down for weaning from invasive mechanical ventilation. However, no such data are available for the withdrawal of NIV. Evidence-based reviews suggest that protocols to manage the weaning and liberation of subjects from Mechanical Ventilation could reduce the time that subjects spend receiving mechanical ventilation. However, no such data about protocolized withdrawal of NIV are available.

Detailed description

A study to compare protocolized weaning from non-invasive ventilation using three potential strategies of weaning from NIV * Stepwise reduction of duration of NIV use, * Stepwise reduction in pressure support of NIV, and * Immediate withdrawal of NIV. Among patients with Acute respiratory failure due to acute exacerbation of COPD.

Conditions

• Chronic Obstructive Pulmonary Disease

Interventions

Type	Name	Description
DEVICE	Noninvasive ventilation	Weaning from noninvasive ventilation for patients with acute exacerbation of COPD

Timeline

• Start date: 2023-08-01
• Primary completion: 2024-08-01
• Completion: 2025-04-01
• First posted: 2025-08-21
• Last updated: 2025-08-21

Locations

1 site across 1 country: Egypt