Trials / Recruiting
RecruitingNCT07132918
HEARTS Trial for Thoracic Cancers
The cARdiac Radiation Therapy Sparing (HEARTS) for Thoracic Cancers
- Status
- Recruiting
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- Sponsor
- University of Wisconsin, Madison · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The goal of this clinical trial is to compare a new way of using magnetic resonance-guided adaptive radiation therapy (MRgART) to the standard of care linear accelerator (LINAC) radiation treatment in people with cancer in the thoracic region near the heart. The main question it aims to answer is whether MRgART affects the heart differently than LINAC. Participants will: * Receive radiation therapy * Undergo MRIs and bloodwork * Complete quality of life questionnaires
Detailed description
This clinical trial, The cARdiac Radiation Therapy Sparing (HEARTS) trial, will compare MR-guided adaptive radiation therapy (MRgART) with substructure sparing to standard of care x-ray based linac RT with whole-heart dose metrics for patients with cancer in the thoracic region based on longitudinal changes in cardiac function using MRI, quality of life, cardiac waveforms, and blood biomarkers.
Conditions
- Non-Small Cell Lung Cancer (Stage III)
- Esophageal Cancer Stage I-III
- Esophagogastric Cancer Stage I-III
- Thymoma and Thymic Carcinoma Stage II-III
- Other Cancers in the Thoracic Region
Interventions
| Type | Name | Description |
|---|---|---|
| RADIATION | MRgART | Magnetic Resonance-guided Adaptive Radiation Therapy (MRgART) is a form of MRgRT that incorporates daily adaptive planning, or making a new treatment plan each treatment, and real-time imaging during treatment delivery. |
| RADIATION | LINAC | Daily 3D x-ray scans will be obtained for radiation delivery to confirm tumor and organ at risk placement. |
Timeline
- Start date
- 2025-10-08
- Primary completion
- 2029-03-01
- Completion
- 2029-03-01
- First posted
- 2025-08-20
- Last updated
- 2026-03-11
Locations
1 site across 1 country: United States
Regulatory
- FDA-regulated device study
Source: ClinicalTrials.gov record NCT07132918. Inclusion in this directory is not an endorsement.