NCT07131800

Objective and Perceptual Characteristics of the Voice After Endotracheal Intubation in Head and Neck Surgery

• Status: Enrolling By Invitation
• Phase: —
• Study type: Observational
• Enrollment: 180 (estimated)
• Sponsor: Clinical Hospital Centre Zagreb · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Introduction: Possible consequences of endotracheal intubation are post-intubation voice changes. Hypothesis: Endotracheal intubation during head and neck surgery is associated with objective and perceptual voice disorders. Research objective: To investigate the short-term and long-term effects of endotracheal intubation on voice quality during head and neck surgery. Material, subjects, methodology and research design: A prospective observational cohort study that will include patients undergoing surgery and endotracheal intubation lasting up to 3 hours. Adult patients divided into three groups will be included in the research: thyroid surgery, parotid gland surgery and abdominal surgery. Videostroboscopy, perceptual and objective acoustic voice analysis will be recorded before surgery, on the second postoperative day, two weeks and 1 month after surgery. Expected scientific contribution of the proposed research: The scientific contribution would be an understanding of the risk factors and the connection of voice disorders after endotracheal intubation, as well as the ability to determine differences in this risk in patients undergoing different operations.

Detailed description

study protocol has been published and is attached below

Conditions

• Voice Disorder Due to Iatrogenic Factor
• Endotracheal Intubation During Surgery
• Thyroid Surgery
• Head and Neck Surgery

Timeline

• Start date: 2024-09-25
• Primary completion: 2025-12-31
• Completion: 2026-03-30
• First posted: 2025-08-20
• Last updated: 2025-08-20

Locations

1 site across 1 country: Croatia