NCT07131579

Intravenous Regional Analgesia of Dexmedetomidine

Regional Intravenous Analgesic Effect of Dexmedetomidine in Knee Surgeries Under Spinal Anesthesia: A Prospective, Randomized, Double-Blind Controlled Study

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Mansoura University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Dexmedetomidine is a highly selective α₂-adrenergic receptor agonist that exerts its effects by inhibiting the release of norepinephrine at presynaptic nerve terminals, leading to reduced sympathetic activity; This mechanism results in analgesia, sedation, and anxiolysis without significant respiratory depression

Detailed description

In the context of intravenous regional anesthesia (IVRA), dexmedetomidine has been employed as an adjuvant to local anesthetics like lidocaine to improve block characteristics; Clinical studies have demonstrated that adding dexmedetomidine to lidocaine in IVRA accelerates the onset of sensory and motor blocks, extends the duration of postoperative analgesia, and reduces the incidence of tourniquet pain

Conditions

• Dexmedetomidine Analgesia
• Knee Surgery

Interventions

Type	Name	Description
DRUG	Normal Saline	equal volume of normal saline
DRUG	Dexmedetomidine	0.5 mcg/kg of dexmedetomidine

Timeline

• Start date: 2026-01-12
• Primary completion: 2026-12-30
• Completion: 2027-08-30
• First posted: 2025-08-20
• Last updated: 2026-01-21

Locations

1 site across 1 country: Egypt