NCT07131293

European Registry Study on Lymphatic Interventions

European Registry Study on Lymphatic Interventions: Towards Standardized Care in CHD-Related Lymphatic Disorders

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 500 (estimated)
• Sponsor: Rigshospitalet, Denmark · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

This European multicenter observational study aims to evaluate the real-world use, timing, and outcomes of lymphatic interventions in patients with congenital heart disease and/or primary lymphatic disorders. The study will examine the effectiveness of diagnostic imaging and interventional techniques, such as lymphatic embolization, in improving clinical symptoms, biomarkers, and fluid-related complications. The central question is whether early diagnosis and targeted intervention can lead to clinically meaningful improvements and reduced need for reintervention. Data collected retrospectively and prospectively from participating centers will help identify predictors of outcome, assess disease severity, and inform standardized diagnostic and therapeutic pathways across Europe.

Detailed description

This is a prospective, multicenter observational study with retrospective components. The study population includes patients who have undergone or are undergoing lymphatic imaging diagnostics and lymphatic interventions at participating centers across Europe. Patients are included both retrospectively (from medical records) and prospectively as part of their routine clinical care.

Conditions

• Lymphatic Disorders
• Plastic Bronchitis
• Protein Losing Enteropathy
• Chylothorax
• Lymphatic Abnormalities

Interventions

Type	Name	Description
PROCEDURE	Lymphatic intervention	This intervention was made as part of their clinical treatment.

Timeline

• Start date: 2026-02-01
• Primary completion: 2030-03-01
• Completion: 2030-03-01
• First posted: 2025-08-20
• Last updated: 2026-01-21

Locations

1 site across 1 country: Denmark