NCT07130721

Assessment of D-dimer and CRP for Cardiovascular Risk Prediction in Hemodialysis Patients

Assessment of Blood Biomarkers (D-dimer and C-Reactive Protein) in Predicting Cardiovascular Complications Among Hemodialysis Patients: A Cross-Sectional Study

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to assess whether two blood markers - C-reactive protein (CRP) and D-dimer - can help predict cardiovascular complications in patients undergoing regular hemodialysis. Cardiovascular disease is a common and serious problem in dialysis patients, and early detection is important. the study will include 100 adult patients from the Hemodialysis Unit at Assiut University Hospital. Participants will be divided into two groups: those with and those without known heart disease. Each participant will have a one-time blood test to measure CRP and D-dimer levels. In addition, an electrocardiogram (ECG) will be done once to check for signs of heart problems.

Detailed description

This cross-sectional study is designed to explore the potential role of hematologic biomarkers in predicting cardiovascular complications among patients undergoing maintenance hemodialysis. Cardiovascular disease is a leading cause of morbidity and mortality in this population, and systemic inflammation and hypercoagulability are thought to contribute significantly to adverse outcomes. C-reactive protein (CRP) is a well-established marker of systemic inflammation, while D-dimer reflects activation of the coagulation and fibrinolytic pathways. Both biomarkers have been associated with increased cardiovascular risk in the general population, but their predictive value in hemodialysis patients remains insufficiently characterized. A total of 100 adult patients on maintenance hemodialysis will be evaluated. The population will be stratified into two groups based on the presence or absence of clinically confirmed cardiovascular disease. Laboratory analysis will include measurement of CRP and D-dimer, and cardiovascular assessment will include a standard 12-lead ECG. Clinical and demographic data will also be collected.

Conditions

• End Stage Renal Disease on Dialysis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	C-Reactive Protein (CRP) Test	Blood samples will be collected once from all participants to measure CRP levels
DIAGNOSTIC_TEST	D-dimer Test	D-dimer levels will be assessed once to evaluate thrombotic risk.
DIAGNOSTIC_TEST	Electrocardiogram (ECG)	A standard 12-lead ECG will be performed once per participant to assess cardiovascular status

Timeline

• Start date: 2025-11-01
• Primary completion: 2026-02-01
• Completion: 2026-05-01
• First posted: 2025-08-19
• Last updated: 2025-08-19

Locations

1 site across 1 country: Egypt