NCT07129681

a Comparison of the Outcomes Following Intra-articular Dextrose 5% Injection Versus Arthrocentesis in Patients With Anterior Disc Displacement With Reduction of the Tomporomandibular Joint

A Comparison of the Outcomes Following Intra-articular Dextrose 5% Injection Versus Arthrocentesis in Patients With Anterior Disc Displacement With Reduction of the Temporomandibular Joint.

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 42 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The Aim of this study is to evaluate the efficacy of intra-articular Dextrose injection with concentration 5% in superior joint space of TMJ in comparison to arthrocentesis in patients with anterior disc displacement with reduction of TMJ who did not respond favorably to conservative treatment and to compare and infer which among the two procedures is more satisfactory, whether dextrose 5% injection or Arthrocentesis.

Detailed description

The Aim of this study is to evaluate the efficacy of intra-articular Dextrose injection with concentration 5% in superior joint space of TMJ in comparison to arthrocentesis in patients with anterior disc displacement with reduction of TMJ who did not respond favorably to conservative treatment and to compare and infer which among the two procedures is more satisfactory, whether dextrose 5% injection or Arthrocentesis.

Conditions

• TMJ Disc Disorder

Interventions

Type	Name	Description
OTHER	dextrose 5%	Dextrose, is an osmotic proliferant which acts by dehydrating the cells at the injection site which utlimately leads to release of cellular fragments that act as chemo attractants and start the inflammatory cascade leading todeposition of collagen
OTHER	Arthrocentesis/Saline	Arthrocentesis , a highly successful, simple and minimally invasive procedure is a safe and simple method for treatment of anterior disc displacement with reduction of TMJ both in short term and long term follow up period, where it is a procedure of removing damaged tissues \&inflammatory mediators.it can be the treatment modality for the for control group

Timeline

• Start date: 2025-10-01
• Primary completion: 2026-10-01
• Completion: 2026-12-01
• First posted: 2025-08-19
• Last updated: 2025-08-19